FR-900520 and FR-900523, novel immunosuppressants isolated from a Streptomyces. II. Fermentation, isolation and physico-chemical and biological characteristics.

نویسندگان

  • H Hatanaka
  • T Kino
  • S Miyata
  • N Inamura
  • A Kuroda
  • T Goto
  • H Tanaka
  • M Okuhara
چکیده

FR-900520 and FR-900523, novel neutral macrolide immunosuppressants, were isolated from the cultured broth of Streptomyces hygroscopicus subsp. yakushimaensis No. 7238. Their molecular formulae were determined as C43H69NO12 and C42H67NO12, respectively. The compounds suppressed immune response in vitro. IC50 values of FR-900520 and FR-900523 for mouse mixed lymphocyte reaction were 0.55 nM and 1.6 nM, respectively. FR-900520, the major component, clearly prolonged skin allograft survival in rats.

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منابع مشابه

The Journal of Antibiotics Fr-900520 and Fr-900523, Novel Immunosuppressants Isolated from a Streptomyces I. Taxonomyof the Producing Strain

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عنوان ژورنال:
  • The Journal of antibiotics

دوره 41 11  شماره 

صفحات  -

تاریخ انتشار 1988